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Indeed, among these miRNAs, transfection of miR-2137 resulted in an increase in the production of the ferroptosis marker lipid peroxidation and ROS in HK2 cells, while transfection of miR-140-3p or miR-205-5p exhibited an inhibitory effect (Figures 6F,G)

The metabolism of tyramine by monoamine oxidase a/B causes oxidative damage to mitochondrial DNA

The imbalance of redox homeostasisresulting in increased oxidative stressis considered a key risk factor that makes the brain vulnerable to aging and progressive neurodegeneration

Professionals conducting controlled research studies

The PBS solution was prepared as described before [75]