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This work adds to the emerging theme that granules play a general role in regulating the function of their components

Notably, mitochondrial dysfunction induces endoplasmic reticulum (ER) stress, excessive reactive oxygen species (ROS) production, aberrant autophagy, apoptosis, and disrupted calcium ion homeostasis, culminating in inflammatory imbalance via activated signaling cascades [13,14,15,16,17]

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The mitochondrial carnitine/acylcarnitine carrier is regulated by hydrogen sulfide via interaction with C136 and C155

FSGS: Focal segmental glomerulosclerosis