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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (Figure 1)
Corneal edema in glaucoma patients after the addition of brinzolamide 1% ophthalmic suspension

Declining B12 despite supplementation may indicate an absorption issue requiring higher-dose supplementation

[Effect of mecobalamin on diabetic neuropathies

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