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Some 1,257 patients with diabetic neuropathy were randomly assigned to receive, in double-blind fashion, placebo or acetyl-L-Carnitine at a dose of 500 or 1,000 mg 3 times a day for 1 year

The combined treatment demonstrated significantly greater efficacy than standard-dose pregabalin or acetyl-l-carnitine alone, in terms of both pain symptoms measured by improvement on the VAS score (+12.8%) and neurosensory symptoms measured by the DN4 tool (+22%)

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Nanometer-sized drug carriers can improve bioavailability, achieve controlled release, enhance the selectivity of therapeutic agents, minimize side effects, and optimize treatment outcomes

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