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Notch2 and Notch4 also influence GBM differentiation and aggressiveness, reinforcing the impact of these pathways on tumor heterogeneity

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Interestingly, pre-treatment of cells with N-acetylcysteine, a precursor of glutathione, and a thiol antioxidant failed to block the depletion of glutathione, generation of ROS, and activation of caspase-3

doi: 10.1093/jjco/hyg026

MitoQ, a mitochondrial supplement , has been shown in studies to enhance acetaldehyde clearance in the liver