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This mechanism is also evident in currently employed anticancer therapies [5]
The study by Yksel et al
[DOI] [PMC free article] [PubMed] [Google Scholar] Jagla E
Replacement of Sec46 by a cysteine or mutation of any of the 3 other amino acids of the catalytic site results in an abrogation or a diminution of GPX4 enzymatic activity [1]
Kombian SB, Mouginot D, Pittman QJ (1997)
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