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24 The anti-inflammatory effects of GLP-1RAs are better understood when these molecular details are uncovered, which may lead to novel therapeutic options for inflammatory diseases

The agency found no clinical need for it when approved versions exist

Do not change or discontinue medications without physician guidance

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Al-Aly emphasized that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach

From a regulatory perspective, the development of NCEs requires the collection of extensive safety data