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Both increased production of ROS, as well as decreased antioxidant function have been shown to mediate the increased accumulation of cellular ROS [7]

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While peripheral ghrelin fails to reach these sites, intracerebroventricular ghrelin administration induces c- fos expression in many of these regions and promotes feeding, confirming that ghrelin acts centrally to convey orexigenic signals (Nakazato et al., 2001

These findings align with recent studies on the interaction between tumor metabolism and the immune microenvironment (78)

doi: 10.1007/s10815-015-0430-5 CrossRefGoogle ScholarPubMed Zare, Z., Rezaei, N

It can also be phagocytosed by other cells in the brain, such as neurons, microglia, and astrocytes