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The age of onset of the renal disease varied from 2 months to 6.4 years but was most common in infancy and early childhood

The second mechanism of action occurs downstream, in the liver

Evidence suggests that valproate, used as a mood stabilizer, is a substrate of OAT1 and homovanillic acid, a metabolite of dopamine, is a substrate of OAT3 (Sekine et al., 2000

Cheng Q, Zou X, Wang Y, Yang Z, Qiu X, Wang S, Yang Y, Yang D, Kim HS, Jia X, Li L, Kwak S-S, Wang W (2024) Overexpression of dehydroascorbate reductase gene IbDHAR1 improves the tolerance to abiotic stress in sweet potato

J Neurosci Res 85(11):24332440 Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y (2011) Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms

Eur Ann Otorhinolaryngol Head Neck Dis 136: 481487
