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10.1523/JNEUROSCI.3269-04.2005 [DOI] [PMC free article] [PubMed] [Google Scholar] Qiu S., Anderson C

Species and strain choices add further limits

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SSRIs and other antidepressants increase BDNF over time, so combining them with exogenous BDNF modulators could theoretically produce additive or unpredictable effects

Dihexa induces spinogenesis in cultured hippocampal neurons Actin-enriched spines increased in number in response to both dihexa (Figure 38B&D) and Nle'-AnglV (Figure 38C&D) following 5 days of treatment at 10 "12 M concentration that started on the 7 th day in vitro (DIV7) the results revealed a near 3-fold increase in the number of spines stimulated by dihexa and greater than 2-fold increase for Nle f -AngIV