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Refrigeration Unlike some medications that require strict refrigeration, vitamin B12 injections come in different formulations, and their storage requirements vary: Cyanocobalamin Injections: Many cyanocobalamin B12 injections can be stored at room temperature (68F to 77F / 20C to 25C) and should be kept away from direct light

[DOI] [PubMed] [Google Scholar] 250.Gallo AS, Berducci MA, Nijhawan S, Nino DF, Broderick RC, Harnsberger CR, Lazar S, Echon C, Fuchs HF, Alvarez F, Sandler BJ, Jacobsen G, Horgan S

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Also, research shows that B12 absorbs best when dissolved in an isotonic solution like saline

2013 October