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This oxidative damage and consequent protein aggregation is significantly present in the brains of persons with AD, which contributes to the neuronal loss in this disorder (FIGURE 2)

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However, because the multistep chemical reaction of protein nitration by peroxynitrite requires the involvement of a metal ion such as ferrous iron [79], the role of iron in APAP hepatotoxicity is independent of the Fenton reaction under normal conditions [80]

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An extensive study of depth dose distribution and projectile fragmentation cross-section for shielding materials using Geant4