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The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network
These same strategies may be ineffective when elevated SAH, adenosine accumulation, toxic burden, creatine demand or impaired clearance is the main bottleneck
Around 1 in 6 people are living with fertility issues
Edaravone easily crosses the blood-brain-barrier and displays a high brain penetration capacity (Jin et al., 2017)
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