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[DOI] [PubMed] [Google Scholar] [161].Spiegelman BM, Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators

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Biochemistry 64 , 44774486 (2025)

For many living with severe asthma, daily life can feel like a balancing act between managing symptoms and coping with the side effects of treatment

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Despite their potential to ameliorate neurodegeneration through upregulation of NRF2 and its target genes, as shown by numerous pre-clinical studies, their molecular off-target effects and concomitant unpredictable side-effects pose an obstacle for clinical trials and approval