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Clinical Pathobiochemistry of Vitamin B12

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Histology may reveal epidermal thinning, vacuolar changes and nuclear elongation of keratinocytes, increases in the number of melanocytes in basal layers, and the presence of numerous melanophages in the papillary dermis.3,9 Electron microscopy will show intracytoplasmic desmosomes, numerous aggregated bundles of tonofilaments in the cytoplasm of keratinocytes, and highly condensed keratohyalin granules.10 In the present case, the results of the 2 histological studies carried out were not consistent with the findings described above and were, rather, indicative of an adverse drug reaction

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When dieting, a B12 deficiency can occur due to the limitation of consumption of foods that are high in B12, such as red meat

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