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The regorafenib investigational arm was concurrently and adaptively randomized against other investigational arms, and regorafenib was ultimately dropped after interim analysis showed a low probability of sufficient improvement in OS as compared with randomized controls

These studies highlight that PPEs biocompatibility and bioactivitiessuch as antibacterial and anticancer propertiesendow nano-drug carriers with excellent compatibility and the ability to inhibit bacterial and cancer cell growth

The data obtained show the Y296A variant reducing more rapidly than the U597C enzyme, indicating that the phenol serves to hinder non-specific reduction

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doi: 10.1016/S0921-8777(97)00045-1

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