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A useful one-sentence framing is that MOTS-c is mechanistically coherent but still early and unproven : the AMPK-pathway rationale is biologically plausible, the animal data is genuinely interesting, and yet there are no published human randomized controlled trials to support specific clinical claims

It removes a barrier, which is fatigue and reduced physical capacity

After CTR1-mediated copper transfer into the cytoplasm, CTR1 shuttles copper to the copper chaperones cytochrome c oxidase copper chaperone (COX17), copper chaperone for superoxide dismutase (CCS) and antioxidant 1 (ATOX1) 20,21

doi: 10.1038/nrclinonc.2015.117

Notably, this resistance is largely exclusive to MF, with some exceptions showing reduced susceptibility to SbIII, hinting at a complex interplay between different resistance pathways ( The overexpression of multidrug resistance proteins, such as MRPA, is another critical factor in MF resistance