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2024, n = 2.48 million

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Subsequently, STATs are phosphorylated and translocated into the nucleus, where they enhance the transcription of target genes (including TGF- , TNF- , IL-2 , IL-6 , IL-8 , MMP9 , Intercellular Adhesion Molecule 1 ( ICAM-1 / CD54 ), STAT1 , and STAT3 ) (81)

Notably, EGCG reduces the accumulation of MDSCs by inhibiting the secretion of cytokines such as inducible nitric oxide synthase (iNOS), Nox2, NF- B, and STAT3

This reprogramming can lead to improved metabolic health, reduced inflammation, and enhanced resistance to diseases such as cancer 12

The antioxidant gene nuclear factor erythroid 2-related factor 2 (NRF2) can significantly inhibit the differentiation of Th17 cells in LN by suppressing ROS, thereby improving prognosis, which also confirms this point (197)