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Importantly, Clusterin/ApoJ is a key component of brain-derived lipoproteins and is therefore critical to brain lipid transport and homeostasis (Merrill et al., 2023), and also plays important roles in immune response modulation, cell death and survival, oxidative stress, and proteotoxic stress (e.g., A build-up and toxicity

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[DOI] [PubMed] [Google Scholar] Ikeda Y., Yamaji R., Irie K., Kioka N., Murakami A

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AOD 9604's clinical trial data reported it to be generally well tolerated with no significant adverse endocrine effects, consistent with its lack of IGF-1 stimulation
