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The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)

The funder had no role in the study design, data collection or analysis, decision to publish, or preparation of the manuscript

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Nelson DL, Cox MM (2014) Princpios de bioqumica de Lehninger, 6 edio edn