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Its ability to reduce pro-inflammatory cytokines and improve microcirculation suggests a powerful role in easing joint pain, muscle fatigue, and connective tissue strain
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doi: 10.1111/j.1530-0277.2008.00729.x
It is uncommon and is seen in endocrine disorders (Addison's disease, Cushing's syndrome, hyperthyroidism and acromegaly), alkaptonuria, hemosiderosis, hyperbilirubinemia, and porphyria
In fact, the liver stores so much B12 that it can take years for a deficiency to develop (EFSA, 2015
