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However, a combination of ACEi and ARB is not recommended, and ACEi/ARB is not recommended for the primary prevention of DKD in patients with diabetes with normal blood pressure and proteinuria (National Kidney Foundation, 2012)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Miller ER, 3rd, Pastor-Barriuso R, Dalal D, et al

Since many engineered enzymes were modified to tether a polyhistidine chain for purification purpose, direct binding using this functionality onto a nickel-based carrier would save the use of binding agents (e.g