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ROS exists in spermatozoa at a certain low controlled concentration, participating in several physiological processes of sperm

Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee T-SW, Zaveri HP, Eid T (2021) Astroglial glutamine synthetase and the pathogenesis of mesial temporal lobe epilepsy

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Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective

FDA later published a determination that it was not withdrawn for reasons of safety or effectiveness , but it is no longer commercially available as an FDA-approved product (FDA, 2013)

Once concentrated in tumors, it acted as a CDT agent by catalyzing the production of oxygen and toxic hydroxyl radicals from hydrogen peroxide and increasing singlet oxygen generation through PPa-mediated PDT