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Nature , 1980

The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids

Moreover, the histidine imidazole Cu 2+ binding (anchoring) is followed when Cu 2+ is in a coordinated state, and this is achieved by the presence of two deprotonated backbone amides (Rivillas-Acevedo et al., 2013)

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Age, sex, nutritional status, adiposity, dietary preferences, habits such as smoking, use of concurrent medications, physiologic states such as pregnancy, pathologic states such as liver disease, and others can affect one or more of the 3 processes listed above, thereby influencing the half-life of psychotropic and other drugs