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Immunity 36 , 834846 (2012)

Contributing factors include: reduced nutritional intake (proteins, essential amino acids, competition between amino acid transporters, vitamin insufficiency [riboflavin: GSSG reductase, nicotinic acid: NADPH, pyridoxine (B 6 ): SAMe pathway], mitochondrial dysfunction: ATP deficiency, down regulation SAMe synthase, oxidation of SAMe pathway enzymes, enhanced GSH utilization: conjugation reactions (toxins, drugs), and overwhelming oxidative challenge

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Unfortunately, many variables that overwhelm your body with oxidative stress and chronic inflammation, like stress, infections, and a poor diet, may result in your body making less than optimal amounts of this master antioxidant which is not uncommon in those with Hashimotos

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