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Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice

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The reduced antioxidant levels can lead to vascular endothelial cell damage, and in conditions such as preeclampsia during pregnancy, for example, the defensive ability of the total plasma antioxidant barrier is unable to overcome oxidative stress

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Thus, TFEB, as a potential therapeutic target, has been associated with many diseases, such as lysosomal storage diseases, neurodegenerative diseases, and cancer (Tan et al., 2022)