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A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years

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This therapeutic strategy allows for the safe continuation of vitamin B12 therapy in patients who have previously experienced incidents of hypersensitivity to various forms of cobalamin, regardless of the route of administration and chemical form

And 100 units, a full syringe, would give you 5 mg, which is more than double the maximum approved weekly dose

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