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Endoplasmic reticulum retention: Mammalian cytoplasmic proteins at fresh synthesis have Specific lysine-containing motifs present at carboxyl groups which act as identifying tags allowing them to be retained in the endoplasmic reticulum

JCI Insight (2018) 3:117

2.3 Adipose tissue function and adipokine secretion in high-altitude adapted populations High-altitude hypoxia not only alters systemic energy metabolism but also reshapes adipose tissue function and its endocrine characteristics, including adipokine secretion profiles