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However, published human pharmacokinetic data comparing oral to injectable absorption at equivalent doses has not been established in peer-reviewed literature

While cyanocobalamin has proved effective in preventing vitamin B12 deficiency, there is increasing evidence that the coenzyme B12 forms have a distinct advantage and better spectrum of action in many specialised applications

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The theoretical advantage is significant

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Overarching Principle The fundamental principle of regulation of medicines is to optimise timely access to effective treatments while reducing the risk of harm from improper use