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Prescribing unapproved drugs is not routine medical practice Without FDA approval or an authorized investigational pathway, licensed providers do not have authority to prescribe experimental compounds as treatment

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Rare but serious side effects may include severe abdominal pain, persistent vomiting, allergic reactions, or signs of gallbladder or pancreatic inflammation

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They also express Bv8, also known as prokineticin 2, which plays an important role in MDSC mediated angiogenesis [253]

Complicating this further: the regulatory picture shifted significantly between 2023 and 2025
