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The association between varicocele and elevated oxidative stress levels has been well-established, with multiple studies confirming higher oxidative stress in infertile men with varicocele compared to their fertile counterparts and those with idiopathic infertility [246,247,248,249,250]

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In common with, and expanding upon the primary considerations for the selection of chemicals (48) and as indicated in previous publications ( 2.1 Availability and international limitations in transport and use of certain chemicals The chemicals were selected to accommodate national and international limitations on use, as the pre-validation reference chemicals will ultimately be intended for use in OECD TGs, with global distribution and use
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