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Physical exercise and particular nutrients, including CIT and leucine, have demonstrated efficacy in upregulating the signaling pathways of PGC-1, SIRT1, and AMPK, thereby facilitating mitochondrial turnover and alleviating oxidative stress (74)

The reliability of evidences was ranked, according to 7 causation criteria, into four levels, with level 1 being highly probable and level 4 being doubtful (Table 2)

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National surveys in the US indicate that the average dietary iron intake is about 12 mg/day in nonpregnant women and 15 mg/day in pregnant women (162)

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