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A defect in a particular pathway can result in either accumulation or lowered levels of its byproducts

Fetal metabolism uses sulfation pathways that become saturated, shunting more drug to the toxic pathway

In our experiments, exogenous rapamycin significantly decreased the proportion of SA--Gal-positive cells and p16 expression, whereas autophagy inhibitors 3-MA and Baf-A1 produced opposite effects

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Introduction Diabetes mellitus, which encompasses both type 1 and type 2 variants, is a metabolic disease characterized by diverse clinical presentations and disease progression patterns

doi: 10.1016/j.tem.2010.06.009 77 LengqvistJMata De UrquizaABergmanACWillsonTMSjvallJPerlmannTet al