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Replacement of Tyr110 in recombinant Y110A decreased both k cat app and 1/ values for the disulfide substrate and GSH in the GSSCys and HEDS assay (Supplementary Figs 18 and 19)

Its genome is a single-stranded positive-sense RNA that contains four structural proteins: spike protein (S), membrane protein (M), nucleocapsid protein (N) and envelope protein (E) ( ACE2 is widespread in different organs, including the respiratory and gastrointestinal tract, the brain, the kidneys, the heart, and vessels, and this is the reason why, although the main viral target still remains the respiratory epithelium, SARS-CoV-2 can potentially infect multiple tissues ( In critical patients, euthyroid sick syndrome or non-thyroidal illness syndrome, characterized by decreased fT3 but normal TSH levels, has been described as probably due to the abnormal hyperinflammatory state: in fact, in most cases, this condition was transient and resolved over time (128, 129)

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It is made up of three amino acids: cysteine, glycine, and glutamic acid