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ZhangWMiikedaAZuckermanJJiaXCharugundlaSZhouZet al

37 Current studies further demonstrated that HIF-1 inhibited two enzymes in FAO, the medium- and long-chain acyl-CoA dehydrogenases MCAD and LCAD

Reasoning that the enzymes encoded by these genes could be responsible for the utilization of l-carnitine and its conversion to BB (Figure 7C), we used comparative genomics tools to identify 3 other organisms that contain the caiTABCDE gene operon (Supplemental Figure 5), and assessed their ability to consume l-carnitine and produce BB (Figure 8)

Moreover, related clinical trials have reported inconsistent LC doses, varied treatment durations, small sample sizes, and possible confounding factors [20]

This raises the question of whether dietary modification could induce changes in the composition of the microbiome, potentially increasing the abundance of beneficial bacteria and reducing TMAO production
L-Carnitine is synthesized in the human brain, liver, and kidneys from the amino acids methionine and lysine
