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Rapid acidification is required to prevent GSH auto-oxidation, GSH and GSSG degradation, as well as to precipitate proteins that interfere with analysis

Stability of amphotericin B 0.05 and 0.5 mg/mL in 20% fat emulsion

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[87], some pollutants, radiation, cigarette smoking, and some drugs/xenobiotics can contribute to OxS

So, free thiols are likely to oxidize post-packaging (to a lesser extent if using metabisulfites), but thiol precursors can also continue to be released into a free state during aging