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Oxidative stress and depletion of cellular GSH are considered key factors in the onset and progression of various chronic and age-related disorders

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

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10.1021/jo000335z 104 KangN.LeeJ.-H.LeeW.KoJ.-Y.KimE.-A.KimJ.-S.et al (2015)

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While not toxic, excessively high doses are usually unnecessary