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The treatment of aged rats with an inhibitor of iNOS or the use of GSNO in vitro demonstrated that SIRT1 is inhibited by S-nitrosylation and this results in p53 and NF-B increased activity with consequent production of pro-inflammatory cytokines [99]

Reactive oxygen species in living systems: source, biochemistry, and role in human disease

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Fibrosis occurs because chronic inflammation kills off liver cells, and specialized cells called hepatic stellate cells rush in to repair the damage by laying down collagen and other fibers

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