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Neuropathological hallmarks of the disease include the abnormal deposition of amyloid -peptide (A) fibrils, the main component of senile plaques (SPs), and the intracellular accumulation of neurofibrillary tangles (NFTs), composed of hyperphosphorylated Tau protein (pTau)

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Stopping semaglutide often leads to weight regain, so most use it long-term under medical supervision

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