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For each cardiovascular outcome, people who had had an event of the same subtype prior to baseline (based on self-reported information) were excluded from the analysis, resulting in different subsamples for each outcome (see electronic supplementary material [ESM] Fig

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The biggest handicap the Panama, Nicaragua or Mexico routes had was the wait until scheduled Pacific shipping was established in late 1849 to carry them to California

The timeline for sphincter improvement in animal studies varies based on administration route and severity of dysfunction

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