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14,15 Extreme stress and eating disorders can disrupt hypothalamic signaling, leading to ovarian dysfunction and anovulation

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Plast Reconstr Surg 2008

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This is especially important for tissues that use a lot of energy, such as the heart and the brain

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These MD simulations revealed that the carbohydrate moiety of the glycated form occupies the DPG binding site, thus preventing it from adopting one of the two possible binding conformations

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