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In contrast, it would appear that the neurologic effects of cobalamin deficiency are due to metabolic disturbances unrelated to purine synthesis because the neurologic deficits may develop independently of the hematologic abnormalities, and folate supplementation will not prevent or reverse these deficits

These are significant exemptions, and they are what make patient-specific compounding legally viable

Importantly, key methodological gaps limit interpretation

[Updated 2022 Jun 5]

B12 injections are available on the NHS when clinically indicated following appropriate blood tests and diagnosis

When NNMT is suppressed, NAD+ levels rise