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In: Taylor, Awasthi YC, editors

Park PH, Sanz-Garcia C, Nagy LE

In a phase II clinical trial (NCT02644369), it was found that an increase in serum choline levels (cholineC3) at week 7 in patients receiving pembrolizumab treatment was significantly associated with better progression-free survival (PFS) and showed a trend of improvement in overall survival (OS)

Along the jawline, this shows up as a slight tightening of the lower face

doi: 10.7150/ijms.10001

IGF-1 gene knockout in mice results in miniature mice that die soon after birth