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There was no evidence for a worsened outcome (reduced cell survival, Figure 1), worsened infarct size (Figure 3), or in the assessment of mitochondrial energy production with metabolic challenges (Figure 4)

WebMD: (1) An overview of Propionyl-L-carnitine, its uses, side effects, interactions, and recommended dose

In 2002, a randomized, double-blind study (N = 333 LOE1b) showed that LC supplementation improved neurophysiological parameters and significantly reduced pain in patients with diabetic PNSDs [72]

Rooney, J

doi:10.3233/JHD-230564

In their meta-analysis combining the results of twelve randomized controlled trials, Veronese and colleagues reported a significant decrease in depression severity after acetylcarnitine supplementation as monotherapy compared with placebo intake or no intervention [143]