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Additionally, ischemia triggers excessive glutamate release, leading to overactivation of NMDA receptors, which in turn causes excitotoxicity, oxidative stress, and neuroinflammation
The reason for this unexpected observation was that paralysis of an essential cellular defense mechanism like autophagy leads to faster accumulation of cellular waste, which triggers an enhanced rate of cell turnover through apoptosis and compensated enhanced regeneration [151]

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References 1.Council for Agricultural Science and Technology
[DOI] [PubMed] [Google Scholar] 250.Dean O, Giorlando F, Berk M

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
