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Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics

Smoked Fish: Nigerian smoked catfish (20172020): B[a]P 122288 g/kg (37) Ghanaian smoked tilapia (20182021): PAH4 85156 g/kg (38) Benin smoked sardinella (20172019): B[a]P 68142 g/kg (42) Kenya smoked Nile perch (2017): PAH4 4298 g/kg ( Grilled Meat: Nigerian suya, beef (2020): B[a]P 1867 g/kg, PhIP 1228 ng/g (37) South African braai, mixed meats (2016): B[a]P 441 g/kg ( Ethiopian grilled lamb (2022): B[a]P 1436 g/kg (46) Singed Meat: Ghana tire-singed beef (20232025): B[a]P 387892 g/kg ( Nigeria tire-singed goat (2024): PAH16 total 1,2402,856 g/kg ( These data demonstrate that traditional processing in current practice generates carcinogen exposures substantially exceeding levels considered acceptable in international food safety frameworks (37, 38)

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