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However, owing to the multifaceted nature of wound healing and chronic wound formation, improper regulation of either ROS production or removal can lead to oxidative stress and impairment of wound healing, contributing to the formation and propagation of chronic wounds

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Consistently, in a CRPS model, the spinal cord showed increased populations of reactive astrocytes and microglia were observed in the spinal cord, along with elevated expression of the M1 marker CD86 and reduced Arg-1 expression, indicating a preferential M1 microglial polarization in NPP (122)

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