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Most currently proposed biomarkers suffer from inadequate sensitivity and specificity, particularly in early-stage disease or asymptomatic patients
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On the other hand, the first allosteric inhibitor of Rv1098c, designated as inhibitor 7 ([N-(5-(azepan-1-ylsulfonyl)-2-methoxy-phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetamide]), was identified by combination with high-throughput screening and structure validation [292]
Tena-Solsona, M., Wanzke, C., Riess, B., Bausch, A
Consequently, porphyrins have been widely used in the development of type II PSs for photodynamic therapy in cancer treatment 62,63
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