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In a primary study using germ-free mice, Braniste et al

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While these findings highlight promising biological activity, it is important to emphasize that current evidence is derived primarily from experimental animal models

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FXR agonists, including chenodeoxycholic acid and obeticholic acid, inhibit hepatic autophagy through Rubicon induction, which is relevant for cholestatic liver disease

It is not commonly found in over-the-counter supplements because it is more expensive and often used in clinical settings