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Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GR, HOPE and HOPE-TOO Trial Investigators

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The lactate shuttle hypothesis further revealed its pivotal roles in oxidative substrate transport and cellular signaling via monocarboxylate transporters (MCTs), leading to its recognition as a potent signaling metabolite, particularly through its receptor GPR81 (6-8)

However, the levels of glutathione can reduce due to age, high blood sugar levels, excessive alcohol use, excessive exercise, exposure to toxins, and illness

doi: 10.1016/j.mam.2011.10.006 98 XiongYXiongYZhangHZhaoYHanKZhangJet al

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